Here's a quilt material I did for fun in substance designer, I've really been having a lot of fun with Designer so this was a nice project to really push my skills. I used this project I found: https://www.artstation.com/artwork/G8X6yd to help create this material and reverse engineered a lot of the techniques used in that material. I also reverse engineered the Auto Mask node created by https://www.artstation.com/oday and even added the feature to increase the number of squares you can mask out. This Auto Mask node helped greatly to assigned patterns to specific squares on the quilt.
The original reference I used to base my quilt off of, was found on Pinterest.
Auto-Mask Node